Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
UV Spectrophotometric Assay of Ketoconazole Oral Formulations
Current Issue
Volume 2, 2014
Issue 5 (October)
Pages: 108-111   |   Vol. 2, No. 5, October 2014   |   Follow on         
Paper in PDF Downloads: 26   Since Aug. 28, 2015 Views: 2425   Since Aug. 28, 2015
Authors
[1]
Safila Naveed, Faculty of Pharmacy, Jinnah University for women, Karachi.
[2]
Lailoona Jaweed, Faculty of Pharmacy, Jinnah University for women, Karachi.
Abstract
Ketoconazole is an antifungal drug use for the treatment of many systemic and external antifungal agents. It is used for the different types of fungi species. It may cause different side effects specifically in males it causes decrease in testosterone concentration so it should be use with caution in males. It is also used in many external fungal infection seborrheic dermatitis. The assay was done by using 3 available brands of ketoconazole in market, different dilution of 100ppm, 50ppm and 25ppm were made and analyzed, percent assay was determine by measuring absorbance. Furthermore absorbance at different concentration was determine and on applying regression it is concluded that there is a linear relationship between concentration and absorption.
Keywords
Ketoconazole, Spectrophotometer, Oral Formulation
Reference
[1]
Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3
[2]
Heeres J, Backx LJ, Mostmans JH, Van Cutsem J (August 1979). "Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent". J. Med. Chem. 22 (8): 1003–5
[3]
Jeanne Hawkins Van Tyle Pharm.D.Ketoconazole; Mechanism of Action, Spectrum of Activity, Pharmacokinetics, Drug Interactions, Adverse Reactions and Therapeutic Use,Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Volume 4, Issue 6, pages 343–373, November-December 198
[4]
Shaligram S. Ranea, , P. Padmaja,Spectrophotometric method for the determination of ketoconazole based on amplification reactions Journal of Pharmaceutical AnalysisVolume 2, Issue 1, February 2012, Pages 43–47
[5]
Mahler C1, Verhelst J, Denis L.Ketoconazole and liarozole in the treatment of advanced prostatic cancer.Cancer. 1993 Feb 1;71(3 Suppl):1068-73.
[6]
Smith EB, Henry JC,Ketoconazole: an orally effective antifungal agent. Mechanism of action, pharmacology, clinical efficacy and adverse effects. Pharmacotherapy. 1984 Jul-Aug;4(4):199-204.
[7]
Y. Vander Heyden, A. Nguyen Minh Nguyet, M.R. Detaevernier, D.L. Massart, J. Plaizier-Vercammen, Journal of Chromatography A, Volume 958, Issues 1–2, 7 June 2002, Pages 191-201
[8]
Van Tyle JH.Ketoconazole. Mechanism of action, spectrum of activity, pharmacokinetics, drug interactions, adverse reactions and therapeutic use. Pharmacotherapy. 1984 Nov-Dec;4(6):343-73.
[9]
D. Borelli, J. L. Bran, J. Fuentes, R. Legendre, E. Leiderman, H. B. Levine, A. Restrepo,D. A. Stevens,Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs,Postgrad Med J Volume 55, Issue 647
[10]
Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D (May 1983). "Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes".J. Clin. Invest. 71 (5): 1495–9.
[11]
Chin TW, Loeb M, Fong IW (August 1995). "Effects of an acidic beverage (Glass of Orange Juice) on absorption of ketoconazole". Antimicrobial Agents and Chemotherapy 39 (8): 1671–588
[12]
Huma Dilshad, Safila Naveed and Baqir Naqvi (2013) Assay of new formulations of isosorbide mononitrate by using uv spectrophotometer : BPJ0000115 - World Research Journal of Medicine Volume : 1 Issue : 1, pg9-10
[13]
Huma Dilshad, Safila Naveed and Ghulam Sarwar (2014) Simple spectrophotometric assay of available brands of Acetaminophen tablets and their comparative study Journal of pharmacy and pharmaceutical sciences Volume 2, Issue 1,1-4
[14]
Safila Naveed, Fatima Qamar, Ghulam Sarwer., (2014) Percentage assay of metformin in different medium using UV- spectrophotometer BPJ0000130 - World Research Journal of Organic Chemistry Volume : 2 Issue : 1, 12-14 ISSN: 2320-3374 & E-ISSN: 2320-5679, http://www.bioinfopublication.org/jouarchive.php?opt=&jouid=BPJ0000130
[15]
Safila Naveed (2014) Simple UV spectrophotometric assay of Atorvastatin API formulation and their comparative study, Global Journal of Medical Research .14(2):35-38. https://globaljournals.org/GJMR_Volume14/4-Simple-UV-Spectrophotometric-Assay.pdf
[16]
Safila Naveed and Fatima Qamar (2014) A simple assay of Esomeprazole Using UV spectrophotometer The Global Journal of Pharmaceutical Research (TGJPR) 3(2); 1921-25,http://www.tgjpr.com/view-article.php?id=3433
[17]
Safila Naveed and Fatima Qamar (2014) Simple UV spectrophotometric assay of Mefenamic acid International Journal of Pharma Sciences and Research (IJPSR) ,5(7):364-366 .http://www.ijpsr.info/ijpsr-v5n7.php
[18]
Safila Naveed, Shabana Naz Shah, Fatima Qamar , Nimra Waheed, and Safeena Nazeer, (2014) simple uv spectrophotometric assay of new formulation gentamycin J App Pharm Vol. 6; Issue 4: 407-410
[19]
Safila Naveed, Shabana Naz Shah, Fatima Qamar , Nimra Waheed, and Safeena Nazeer, (2014) Simple UV spectrophotometric assay of Lincomycin, IJPRDD, 1 (2),10-12.
[20]
Safila Naveed* and Amber Nawab (2014) Assay of LVFX (levofloxacin) in different formulation by UV spectroscopy IJPRDD, 1 (2), 13-16.
[21]
Safila Naveed and Fatima Qamar (2014) Simple UV spectrophotometric assay of Metronidazole Open Access Library Journal, 1: e615:1-4. http://dx.doi.org/10.4236/oalib.1100615.
[22]
Huma Dilshad and Safila Naveed (2013) Manufacturing of new formulations of Isosorbide dinitrate by direct compression method and their comparative evaluation with different brands available in the market. American Based Research journal ISSN (2304-7151) Volume 2, Issue 8 pg81-88 Impact Factor 1.5.
[23]
Huma Dilshad and Safila Naveed (2014) Manufacturing Of New Formulations Of Isosorbide Mononitrate By Dry Granulation Method And Their Comparitive Evaluation With Brands Available In The Market IRJP 5(3):168-171 http://www.irjponline.com/admin/php/uploads/2126_pdf.pdf
[24]
Safila Naveed*, Huma Dilshad Fatima Qamar and Ghulam Sarwar(2014) Manufacturing of New Formulations Of Ferrous Fumerate By Direct Compression Method Journal of pharmacy and pharmaceutical sciences Volume 2, Issue 1, 5-8
[25]
Huma Dilshad, Safila Naveed and Asma Rafiq (2014) Comparitive Study of Four Different Brands Of acetaminophen Available In Karachi. WJPS 2(6): 586-590.http://wjpsonline.org/current_issue.php
[26]
Huma Dilshad, Safila Naveed1* and Nimra Waheed (2014) Comparitive Study of Four Different Brands of Captopril Available In Karachi. IRJP : 5(5), 374-377 http://www.irjponline.com/admin/php/uploads/2170_pdf.pdf
[27]
Safila Naveed and Fatima Qamar (2014) Comparative study of different Brands of Alprazolam. Global Journal of Medical Research 14(3): 25-28. https://globaljournals.org/GJMR_Volume14/5-Comparative-Study-of-Different-Brands.pdf
[28]
Safila Naveed* and Nimra Waheed (2014) Comparative Study of Three Different Brands of Doxycycline Capsules Available in Karachi Open Access Library Journal, 1, 1-7. http://dx.doi.org/10.4236/oalib.1100458 Journalhttp://www.oalib.com/paper/3052751#.U5GpAXKSytk
[29]
Safila Naveed ,Huma Dilshad, and Lailoona Jaweed (2014) Comparitive Study of Four Different Brands Of Ranitidine Available In Karachi Mod Chem appl 2: 125.doi:10.4172/2329-6798.1000125 file:///C:/Users/Naveed/Downloads/2329-6798-2-125%20(1).pdf
[30]
Dr. Safila Naveed and Fatima Qamar (2014) Comparative study of Metronidazole formulations DHR International Journal Of Pharmaceutical Sciences (DHR-IJPS) ISSN: 2278-8328, Vol. 5, Issue 2, 111-116
[31]
Safila Naveed* ,Huma Dilshad, and Samreen Aziz (2014) Comparitive Study of Different Brands of Atenolol Available In Karachi. MJPMS Mintage journal of Medical and pharmaceutical Sciences , Vol 3 Issue 3,17-19.
[32]
Safila Naveed and Fatima Qamar (2014) Comparative Analysis of different brands of Diclofenac Sodium MJPMS Mintage journal of Medical and pharmaceutical Sciences,Vol 3 Suppl 3:
[33]
Huma Dilshad, Safila Naveed* and Safoora Ahad (2014) Comparitive Study of Different Brands of Tizanidine IJPRDD, 1 (2),1-8.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-, Open Science Publishers - All Rights Reserved