Short Term Administration of High Dosed Long Acting Oxytetracycline Alters Serum Biochemical and Electrolyte Level in Goat
[1]
Zohaib Ahmed Bhutto, Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Science, Uthal, Pakistan.
[2]
Toufique Ahmed Qureshi, Faculty of Veterinary Sciences, Shaheed Benazir Bhutto University of Veterinary and Animal Sciences, Sakrand, Pakistan.
[3]
Shamsuddin Bughio, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan.
[4]
Farman Ali Siyal, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan.
[5]
Mohammad Asif Arain, Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Science, Uthal, Pakistan.
[6]
Jan Muhammad Shah, Faculty of Veterinary Sciences, Shaheed Benazir Bhutto University of Veterinary and Animal Sciences, Sakrand, Pakistan.
[7]
Benazir Abbasi, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan.
[8]
Aneela Parveen Khuhro, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan.
[9]
Niaz Ali Kaka, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan.
The current study examined the effects of oxytetracyclinelong acting (OXY LA) on blood biochemical variables and electrolytes in goats. Goats were administered OXY LA at high dose rate of 30mg/kg BW intramuscularly for 07 days with an interval of 48 h. Blood samples were collected before (0) and at various time points for 148 h post treatment. The results showed that the serum concentrations of glutamic pyruvic transaminase, glutamic oxaloacetate transaminase and alkaline phosphatase increased (P<0.01) from 6–72 h and (P<0.05) at 96 and 120 h post drug administration compared to control (0 h) and then the concentrations returned to base-line at 148 h. The serum triglycerides, total protein, creatinine and urea increased (P<0.01) from 6–72 h and (P<0.05) at 96 h and then returned to pretreatment value at 120 h following drug administration. Serum calcium level decreased (P<0.05) from 6-148 h whereas serum phosphorus and magnesium levels increased (P<0.05) from 12 to 120 h following OXY LA treatment. The results indicate that the administration of high dosed OXY LA significantly alters serum biochemical and electrolyte level (by chelation) in goat. However, these effects were concentration dependent and the values returned to baseline once the drug cleared from the body.
Oxytetracycline Long Acting, Liver and Kidney Markers, Biochemical, Electrolytes, Goats
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