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Biological Effects of Arctiin from Some Medicinal Plants of Asteraceae Family
Current Issue
Volume 4, 2016
Issue 5 (October)
Pages: 41-47   |   Vol. 4, No. 5, October 2016   |   Follow on         
Paper in PDF Downloads: 46   Since Oct. 15, 2016 Views: 1014   Since Oct. 15, 2016
Motahhareh Tourchi-Roudsari, Medical Biology and Genetic Department, Medical Faculty, Gaziantep University, Gaziantep, Turkey.
Ahmet Arslan, Medical Biology and Genetic Department, Medical Faculty, Gaziantep University, Gaziantep, Turkey.
Mehrdad Iranshahi, Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran.
Arctiin is a lignan found in many plants of the Asteraceae family that have had various biomedical applications for many years. Arctiin possesses various biological features such as antiinflammatory, antioxidative, antiproliferative, and antitumor effects. The present review will discuss reports on biological activities of arctiin from 1984 onwards.
Asteraceae, Arctiin, Biological Activity, Bioactive Compound
Cowan MM. Plant products as antimicrobial agents. Clinical microbiology reviews. 1999; 12(4): 564-82.
Joy P, Mathew S, Skaria BP. Kerala Agricultural University Aromatic and Medicinal Plants Research Station Odakkali. Asamannoor PO Ernakulam District, Kerala, India. 1998.
Cathrine L, Nagarajan N. Preliminary phytochemical analysis and antibacterial activity of leaf extracts of Vitexleucoxylon LF. International Journal of Current Pharmaceutical Research. 2010; 3(2).
Mahesh B, Satish S. Antimicrobial activity of some important medicinal plant against plant and human pathogens. World journal of agricultural sciences. 2008; 4(5): 839-43.
Panda S, Thatoi H, Dutta S. Antibacterial activity and phytochemical screening of leaf and bark extracts of Vitexnegundo l. from similipal biosphere reserve, Orissa. J Med Plant Res. 2009; 3(4): 294-300.
Roudsari MT, Bahrami AR, Dehghani H, Iranshahi M, Matin MM, Mahmoudi M. Bracken-fern Extracts Induce Cell Cycle Arrest and Apoptosis in Certain Cancer Cell Lines. Asian Pacific Journal of Cancer Prevention. 2012; 13(12): 6047-53.
Tourchi-Roudsari M. Multiple Effects of Bracken Fern under in vivo and in vitro Conditions. Asian Pacific journal of cancer prevention: APJCP. 2013; 15(18): 7505-13.
Stevens P. Angiosperm Phhylogeny Website Version 3, maio 2005 http: www. Mobot. Org/MOBOT/research. APweb [Links]. 2001.
Bremer K, Anderberg AA. Asteraceae: cladistics and classification1994.
Arino A, Arberas I, Renobales G, Domínguez JB. Influence of extraction method and storage conditions on the volatile oil of wormwood (Artemisia absinthium L.). European Food Research and Technology. 1999; 209(2): 126-9.
Setzer WN, Vogler B, Schmidt JM, Leahy JG, Rives R. Antimicrobial activity of Artemisia douglasiana leaf essential oil. Fitoterapia. 2004; 75 (2): 192-200.
Judzentiene A, Mockute D. The inflorescence and leaf essential oils of Tanacetumvulgare L. var. vulgare growing wild in Lithuania. Biochemical systematics and ecology. 2005; 33 (5): 487-98.
Larocque N, Vincent C, Belanger A, Bourassa J-P. Effects of tansy essential oil from Tanacetumvulgare on biology of oblique-banded leafroller, Choristoneurarosaceana. Journal of chemical ecology. 1999; 25 (6): 1319-30.
Fraisse D, Carnat A, Viala D, Pradel P, Besle JM, Coulon JB, et al. Polyphenolic composition of a permanent pasture: variations related to the period of harvesting. Journal of the Science of Food and Agriculture. 2007; 87 (13): 2427-35.
Ivanescu B, Vlase L, Corciova A, Lazar M. HPLC-DAD-MS study of polyphenols from Artemisia absinthium, A. annua, and A. vulgaris. Chemistry of natural compounds. 2010; 46 (3): 468-70.
Ferracane R, Graziani G, Gallo M, Fogliano V, Ritieni A. Metabolic profile of the bioactive compounds of burdock (Arctiumlappa) seeds, roots and leaves. Journal of pharmaceutical and biomedical analysis. 2010; 51 (2): 399-404.
Kurkin V, Sharova O. Flavonoids from Calendula officinalis flowers. Chemistry of natural compounds. 2007; 43 (2): 216-7.
Kalvatchev Z, Walder R, Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomedicine & pharmacotherapy. 1997; 51 (4): 176-80.
Zidorn C, Grass S, Ellmerer EP, Ongania K-H, Stuppner H. Stilbenoids from Tragopogonorientalis. Phytochemistry. 2006; 67 (19): 2182-8.
Williams CA, Harborne JB, Geiger H, Hoult JRS. The flavonoids of Tanacetumparthenium and T. vulgare and their anti-inflammatory properties. Phytochemistry. 1999; 51 (3): 417-23.
Xie G, Schepetkin IA, Quinn MT. Immunomodulatory activity of acidic polysaccharides isolated from Tanacetumvulgare L. International immunopharmacology. 2007; 7(13): 1639-50.
Dembitsky VM. Bioactive cyclobutane-containing alkaloids. Journal of natural medicines. 2008; 62 (1): 1-33.
Szakiel A, Ruszkowski D, Janiszowska W. Saponins in Calendula officinalis L.–structure, biosynthesis, transport and biological activity. Phytochemistry Reviews. 2005; 4(2-3): 151-8.
Bora KS, Sharma A. Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. Journal of ethnopharmacology. 2010; 129(3): 403-9.
Sarker SD, Laird A, Nahar L, Kumarasamy Y, Jaspars M. Indole alkaloids from the seeds of Centaureacyanus (Asteraceae). Phytochemistry. 2001; 57(8): 1273-6.
Saklani A, RanjanSahoo M, Dutt Mishra P, Vishwakarma R. Saussureaheteromalla (D. Don) Hand.-Mazz.: A new source of arctiin, arctigenin and chlorojanerin. Indian Journal of Chemistry-Part B OrganicIncluding Medicinal. 2011; 50(4): 624.
Ganellin CR, Triggle DJ. Dictionary of pharmacological agents: CRC Press; 1996.
MacRae WD, Towers GN. Biological activities of lignans. Phytochemistry. 1984; 23 (6): 1207-20.
Morita K, Nishijima Y, Kada T. Chemical nature of a desmutagenic factor from burdock (ArctiumlappaLinne). Agricultural and biological chemistry. 1985; 49(4): 925-32.
Shinohara K, Kuroki S, Miwa M, Kong Z-L, Hosoda H. Antimutagenicity of dialyzates of vegetables and fruits. Agricultural and biological chemistry. 1988; 52(6): 1369-75.
Ryu SY, Ahn JW, Kang YH, Han BH. Antiproliferative effect of arctigenin and arctiin. Archives of Pharmacal Research. 1995; 18 (6): 462-3.
Moritani S, Nomura M, Takeda Y, Miyamoto K-i. Cytotoxic components of bardanaefructus (goboshi). Biological and Pharmaceutical Bulletin. 1996; 19(11): 1515-7.
Hirose M, Yamaguchi T, Lin C, Kimoto N, Futakuchi M, Kono T, et al. Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague–Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer letters. 2000; 155(1): 79-88.
Iwakami S, Wu J, Ebizuka Y, Sankawa U. Faculty of Pharmaceutical Sciences, University of Tokyo, Japan. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo). 1992; 40(5): 1196-8.
Ichikawa K, Kinoshita T, Nishibe S, Sankawa U. The Ca2+ antagonist activity of lignans. Chemical & pharmaceutical bulletin. 1986; 34(8): 3514-7.
Wu J-G, Wu J-Z, Sun L-N, Han T, Du J, Ye Q, et al. Ameliorative effects of arctiin from Arctiumlappa on experimental glomerulonephritis in rats. Phytomedicine. 2009; 16(11): 1033-41.
Lee S, Shin S, Kim H, Han S, Kim K, Kwon J, et al. Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-kB pathways. Journal of Inflammation. 2011; 8: 16.
Bae S, Lim KM, Cha HJ, An I-S, Lee JP, Lee KS, et al. Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells. Biological research. 2014; 47(1): 50.
Ray PD, Huang B-W, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cellular signalling. 2012; 24(5): 981-90.
Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY). 2012; 4(6): 431.
Colavitti R, Finkel T. Reactive oxygen species as mediators of cellular senescence. IUBMB life. 2005; 57(4‐5): 277-81.
Ambros V, Lee RC. Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning. RNA Interference, Editing, and Modification: Springer; 2004. p. 131-58.
Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends in cell biology. 2007; 17(3): 118-26.
Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncology reports. 2008; 19(3): 721-7.
Yoo J-H, Lee HJ, Kang K, Jho EH, Kim CY, Baturen D, et al. Lignans inhibit cell growth via regulation of Wnt/β-catenin signaling. Food and Chemical Toxicology. 2010; 48(8): 2247-52.
Huang DM, Guh JH, Chueh SC, Teng CM. Modulation of anti‐adhesion molecule MUC‐1 is associated with arctiin‐induced growth inhibition in PC‐3 cells. The Prostate. 2004; 59(3): 260-7.
Shoeb M, Macmanus S, Kong-Thoo-Lin P, Celik S, Jaspars M, Nahar L, et al. Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaureapamphylica (Asteraceae). DARU Journal of Pharmaceutical Sciences. 2007; 15(3): 118-22.
Ming DS, Guns E, Eberding A, Towers G. Isolation and characterization of compounds with anti-prostate cancer activity from Arctiumlappa L. using bioactivity-guided fractionation. Pharmaceutical biology. 2004; 42(1): 44-8.
Takasaki M, Konoshima T, Komatsu K, Tokuda H, Nishino H. Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Letters. 2000; 158(1): 53-9.
Hirose M, Nishikawa A, Shibutani M, Imai T, Shirai T. Chemoprevention of heterocyclic amine‐induced mammary carcinogenesis in rats. Environmental and molecular mutagenesis. 2002; 39(2‐3): 271-8.
Shoeb M, MacManus SM, Kumarasamy Y, Jaspars M, Nahar L, Thoo-Lin PK, et al. Americanin, a bioactive dibenzylbutyrolactonelignan, from the seeds of Centaureaamericana. Phytochemistry. 2006; 67(21): 2370-5.
Shoeb M, MacManus SM, Jaspars M, Kong-Thoo-Lin P, Nahar L, Celik S, et al. Bioactivity of two Turkish endemic Centaurea species, and their major constituents. RevistaBrasileira de Farmacognosia. 2007; 17(2): 155-9.
Ma ST, Liu Dl, Deng Jj, Niu R, Liu Rb. Effect of Arctiin on Glomerular Filtration Barrier Damage in STZ‐Induced Diabetic Nephropathy Rats. Phytotherapy Research. 2013; 27(10): 1474-80.
Lu L-c, Zhou W, Li Z-h, Yu C-p, Li C-w, Luo M-h, et al. Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats. Planta medica. 2012; 78(12): 1317-23.
Min B, Lee H, Song JH, Han MJ, Chung J. Arctiin inhibits adipogenesis in 3T3-L1 cells and decreases adiposity and body weight in mice fed a high-fat diet. Nutrition research and practice. 2014; 8(6): 655-61.
Arslanyolu M, Erdemgil F. Evaluation of the antibacterial activity and toxicity of isolated arctiin from the seeds of Centaureasclerolepis. J Fac Pharm. 2006; 35(2): 103-9.
Xie L-H, Ahn E-M, Akao T, Abdel-Hafez AA-M, Nakamura N, Hattori M. Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria. Chemical and pharmaceutical bulletin. 2003; 51(4): 378-84.
Arslanyolu M, Erdemgil F. Evaluation of the antibacterial activity and toxicity of isolated arctiin from the seeds of Centaureasclerolepis. Ankara EczFakDerg. 2006; 35(2): 103-9.
Lee GT, Cha HJ, Lee KS, Lee KK, Hong JT, Ahn KJ, et al. Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes. International journal of molecular medicine. 2014; 33(3): 640-8.
Cha HJ, Lee GT, Lee KS, Lee KK, Hong JT, Lee NK, et al. Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes. Molecular medicine reports. 2014; 10(3): 1363-70.
Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biological and Pharmaceutical Bulletin. 2010; 33(7): 1199-205.
Shilova I, Semenov A, Kuvacheva N, Suslov N, Mustafin R. Isolation, identification, and nootropic activity of compounds in Alfrediacernua chloroform extract. Pharmaceutical Chemistry Journal. 2012: 1-6.
Wang G-x, Han J, Feng T-t, Li F-y, Zhu B. Bioassay-guided isolation and identification of active compounds from FructusArctii against Dactylogyrusintermedius (Monogenea) in goldfish (Carassiusauratus). Parasitology research. 2009; 106(1): 247-55.
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