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Abortifacient Potentials of Zingiberaceae Aframomum Melegueta (Alligator Pepper) in Adult Female Wistar Rats
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Volume 4, 2016
Issue 1 (February)
Pages: 1-5   |   Vol. 4, No. 1, February 2016   |   Follow on         
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Ekhator C. N., Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
M. I. Ebomoyi, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Benin, Benin City, Nigeria.
This study investigates the abortifacient potential of aqueous seed extract of Alligator pepper (zingiberaceae Aframomum Melegueta) in pregnant rats. In a bid to achieve this objective, seven female rats were paired with seven male rats of proven fertility from an initial pilot study. After pregnancy was achieved, the males were removed and female rats 1 – 5 served as the experimental group while female rats 6 and 7 served as the control group. The experimental group receives 2ml/kg single dose of alligator pepper extracts intra-peritoneal at the 4th day while the control was given 2ml/kg distill water orally. Thereafter, the weights of the animals were monitored for the next 17 days. The group fed aqueous seed extract of Alligator pepper showed weight loss in the 2nd trimester (206.40±36.77g) compared to weight in the 1st trimester (215.20±41.99g) but then gain weight again in the 3rd trimester while the control had a progressive weight gain. At the end of pregnancy, while the control produced litters, the experimental rats did not produce any litter. The results of this study showed that aqueous seed extract of Alligator pepper is abortifacient and this was noted in the 2nd trimester. There is therefore need to communicate the danger pregnant women are exposed to, when this substance is used as an ingredient in food or served during religious rites and cultural practices.
Aframomum Melegueta, Pregnancy, Abortifacient
Ajaiyeoba, E. O. and Ekundayo, O. (1999). Essential oil constituents of Aframomum melegueta (Roscoe) K. Schum. seeds (alligator pepper) from Nigeria. Flavour and Fragrance J.; 14(2): 109-111.
Chin, H.B., Sipe, T.A., Elder, R., and Mercer, S.L. (2012). The Effectiveness of Group-Based Comprehensive Risk-Reduction and Abstinence Education Interventions to Prevent or Reduce the Risk of Adolescent Pregnancy, Human Immunodeficiency Virus, and Sexually Transmitted Infections. American Journal of Preventive Medicine; 42 (3): 272–294.
Clark, W.H., Hassoun, D., Gemzell-Danielsson, K., Fiala, C. and Winikoff, B. (2005). Home use of two doses of misoprostol after mifepristone for medical abortion: a pilot study in Sweden and France. Eur. J. Contracept. Reprod. Health Care; 10(3): 184-191.
Denton, D.A. (1982). The hunger for Salt. Berlio Springer-Verlag. 4: 6-12.
DiCenso, A., Guyatt, G., Willan, A., and Griffith, L.(2002). Interventions to reduce unintended pregnancies among adolescents: systematic review of randomised controlled trials. BMJ; 324 (7351): 1426.
Hanson, S.J., Burke, and Anne, E. (2010). Fertility control: contraception, sterilization, and abortion. In Hurt, K. Joseph; Guile, Matthew W.; Bienstock, Jessica L.; Fox, Harold E.; Wallach, Edward E. The Johns Hopkins manual of gynecology and obstetrics (4thed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 382–395.
Inegbenebor, U., Ebomoyi, M.I., Onyia, K.A., Amadi, K. andAigbiremolen, A.E. (2009a). Effect of alligator pepper (zingiberaceae Aframomum melegueta) on first trimester pregnancy in Sprague dawley rats. Nigerian Journal of Physiological Sciences; Vol. 24, No. 2, pp. 161-164.
Inegbenebor, U. Ebomoyi, M.I., Onyia, K.A., Amadi, K. and Aigbiremolen, A.E. (2009b). Effect of alligator pepper (zingiberaceae Aframomum melegueta) on gestational weight gain. Nigerian Journal of Physiological Sciences; Vol. 24, No. 2, pp. 165-169.
Johri, R.K. and Zutshi, V. (1992). An Ayurvedic formulation ‘Trikatu’ and its constituents. J. Ethnopharmacol; 37: 85–91.
Piyachaturawat, P., Glinsukon, T. and Peungvicha, P. (1982). Postcoital antifertility effect of piperine. Contraception; 26: 625–33.
Rang, Humphrey, P., Dale, Maureen M., Ritter, James, M. and Flower (2012). The reproductive system. Rang and Dale's pharmacology (7thed). Edinburgh: Elsevier/Churchill Livingstone. Pp. 426.
Sitruk-Ware, R.L., Menard, J. and Rad, M. (2007). Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen. Contraception. 75: 430-437.
Taliaferro, L. A., Sieving, R., Brady, S. S., and Bearinger, L.H. (2011). We have the evidence to enhance adolescent sexual and reproductive health Adolescent medicine: State of the Art Reviews; 22 (3): 521–543.
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