Maternal Exposure of Mouse to Low-Dose of Trichloroethane is Associated with Increased Birth Weight and Early Neonatal Neurobehavioral Abnormalities
[1]
Mohamed A. Al-Griw, Division of Developmental Biology, Zoology Department, Faculty of Science, University of Tripoli, Tripoli, Libya.
[2]
Massaud S. Maamar, Division of Developmental Biology, Zoology Department, Faculty of Science, University of Tripoli, Tripoli, Libya.
[3]
Naser M. Salama, Division of Developmental Biology, Zoology Department, Faculty of Science, University of Tripoli, Tripoli, Libya.
[4]
Lubna N. Algadi, Division of Developmental Biology, Zoology Department, Faculty of Science, University of Tripoli, Tripoli, Libya.
[5]
Abdul Hakim S. Elnfati, Division of Developmental Biology, Zoology Department, Faculty of Science, University of Tripoli, Tripoli, Libya.
[6]
Emad M. Bennour, Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya.
Maternal exposure to environmental chemicals can adversely affect fetal health. This study aims to identify, in-vivo, the risk of maternal exposure to trichloroethane (TCE) on the birth weight and the neurobehavioral performance of newborns. Groups of female albino mice (F0 generation) were injected intraperitoneally twice weekly for three weeks with TCE (100 and 400 µg/kg BW). Animals were followed up for signs of toxicity and mortality. Neonate's motor behavior including large movement (crawling, pivoting, righting) and small movement (tremor) were assessed. No toxicity adverse signs or mortality were observed in the animals (F0 generation) treated with TCE. The results showed that TCE exposure led to a significant increase in the F1 mouse body weight compared to controls. The results also showed that tremor of neonates of dams exposed to TCE (100µg/kg and 400µg/kg BW) were significantly increased when assessed on postnatal day-1 (PND-1). These findings provide support to a role of the environmental toxicant, TCE, in abnormalities in birth weight and neonatal neurobehavior.
Environmental Toxicant, Trichloroethene, Motor Behavior, Tremor, Mouse Neonate
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