Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Abortifacient Efficacy of Moringa oleifera Leave: An Experimental Study on Adult Female Wistar Rats
Current Issue
Volume 3, 2015
Issue 6 (December)
Pages: 269-272   |   Vol. 3, No. 6, December 2015   |   Follow on         
Paper in PDF Downloads: 24   Since Dec. 9, 2015 Views: 971   Since Dec. 9, 2015
Ekhator C. N., Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
Osifo U. C., Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
It is the aim of this study to investigate the abortifacient potential of Moringa oleifera leaves indicated by weight changes on pregnant Sprague-Dawley rats. In a bid to achieved this objective, fifteen adult albino rats (5 males and 10 females) were obtained from the animal holding of Ambrose Alli University, Ekpoma. Female rats (M1 – M5) served as the experimental group while female rats (C1 and C5) served as the control group. Each rat in both groups was given 20g of normal rat chow and water ad libitum throughout the experiment. After the confirmation of pregnancy, 3g of M. oileifera was added to 17g of normal rat chow to form the experimental diet for M1 – M5 from the 5th day to 15th day. Our results showed progressive body weight gain in the control from the 6th day to 21st day. On the other hand, the test group (fed M. oleifera leaves) showed a reduction in body weight after mating to about the 7th day and started gaining weight from the 8th day to the end of the 3rd trimester. At the end of the 23rd day, only the control produces litters while the test did not produced any litter. This finding revealed that M. oleifera leaves may be abortifacient and it abortifacient potential occur in the 1st trimester of pregnancy.
Moringa oleifera, Abortifacient, Female Rats
Abt AB, Oh JY, Huntington RA, Burkhart KK: Chinese herbal medicine induced acute renal failure. Archives of Internal Medicine 1995, 155: 211-212.
Ahmed M, Ahamed RN, Aladakatti RH, Ghosesawar MG. (2002). Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats. J Basic ClinPhysiol Pharmacol; 13: 51–59.
Bury RW, Fullinfaw RO: Problem with herbal medicines. Medical Journal of Australia 1987, 146: 324-325.
Chin, H. B., Sipe, T. A., Elder, R., and Mercer, S. L. (2012). "The Effectiveness of Group-Based Comprehensive Risk-Reduction and Abstinence Education Interventions to Prevent or Reduce the Risk of Adolescent Pregnancy, Human Immunodeficiency Virus, and Sexually Transmitted Infections". American Journal of Preventive Medicine; 42 (3): 272–294.
Hanson, S. J., Burke, and Anne, E. (2010). "Fertility control: contraception, sterilization, and abortion". In Hurt, K. Joseph; Guile, Matthew W.; Bienstock, Jessica L.; Fox, Harold E.; Wallach, Edward E. The Johns Hopkins Manual of Gynecology and Obstetrics (4thed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 382–395.
Keay R. W. J. (1989). Trees of Nigeria. New York: Oxford University Press.
Kloucek P, Polesny Z, Svobodova B, Vlkova E, Kokoska L: Antibacterial screening of some Peruvian medicinal plants used in Callería District. Journal of Ethnopharmacology 2005, 99: 309-312.
Langlois-Klassen D, Kipp W, Jhangri GS, Rubaale T: Use of traditional herbal medicine by AIDS patients in Kabarole district, Western Uganda. American Tropical and Medical Hygiene 2007, 77: 757-763.
Nath, D. and Sethi, N. (1992). Commonly used Indianabortifacient plants with special reference to their teratologic effect in rats. JEthnopharmacol, 36: 147: 154.
Nnorom IC, Osibanjo O, Eleke C: Evaluation of human exposure to Lead and Cadmium from some local Nigerian Medicinal preparations. Journal of Applied Science 2006, 6: 2907-2911.
Olsen, A. (1987). Low technology water purification by bentonite clay and moringa olifera seeds flocculation as performed in Sudanese Village. Effects of schistosomasonicericaiac. Water and resources, 21, 81-92.
Oluduro A. O. and Aderiye B. I. (2007). Efficacy of Moringaoleifera seed extract on theMicroflora or Surface and Underground Water. Journal of Plant Science, 2(4), 453-458.
Oshikoya KA, Njokanma OF, Chukwura HA, Ojo OI: Adverse drug reactions in Nigerian children. Paediatric and Perinatal Drug Therapy 2007, 8: 81-88.
Prakash, A. O. and Mathur, R. (1976). Screening of Indian plants for anti fertilityactivity. Indian J. Exp. Biol. 14,623.
Ram, J. (1994). Moringa a highly nutritious vegetable tree. Tropical Rural and Island. A toll Development Experimental Station (TRADES) Technical Bulletin No. 2.
Rang, H. P., Dale, M. M., Ritter, J., and Flower, M. (2012)." The reproductive system". Rang and Dale's pharmacology (7thed). Edinburgh: Elsevier/Churchill Livingstone. p. 426.
Shukla S, Mathur R, Prakash AO. (1988). Biochemical and physiological alterations in female reproductive organs of cyclic rats treated with aqueous extract of Moringaoleifera Lam. ActaEur Fertil; 19(4): 225-32.
Sitruk-Ware, R.L., Menard, J. and Rad, M. (2007). Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen. Contraception; 75: 430-437.
Taliaferro, L. A., Sieving, R., Brady, S. S., and Bearinger, L.H. (2011)." We have the evidence to enhance adolescent sexual and reproductive health Adolescent Medicine: State of the art Reviews; 22 (3): 521–543.
Valia R. V., Patil V. K., Patel Z. N. and Kapadia P. K. (1993). Physiological responses of drumstick (Moringaoleifera) land to varying levels of ESP. Indian Journal of Plant Physiology, 36(4), 261-262.
WHO Media Centre: Traditional Medicine. Fact sheet N°134 2008. [http://www.who.int/mediacentre/factsheets/fs134/en/] webcite (Accessed June 2011).
Zade V, Pare S, Dabhadkar D, Chondekar R. Abortifacient efficacy of Moringa oleiferain albino rats. Int J PhramacolBiol Sci. 2010; 4: 133–138.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
Copyright © 2013-, Open Science Publishers - All Rights Reserved