Effect of Lisinopril, an Angiotensin-Converting Enzyme Inhibitor, on Fibrotic Liver Regeneration
Hepatic fibrosis resulted in defective liver regeneration following partial hepatectomy. Angiotensin converting enzyme (ACE) inhibitor, lisinopril enhances liver regeneration and reduces fibrosis. Present study is conducted to evaluate the efficacy of ACE inhibitor, lisinopril on the fibrotic liver regeneration. Six weeks old female Sprague-Dawley rats were made fibrotic by intraperitoneal administration of carbon tetrachloride at the dose of 1.5 ml/kg for seven weeks while vehicle received olive oil at the same dose for the same duration. Vehicle and fibrotic control group was given saline (1ml) while treated group received lisinopril (2.5mg/kg) orally for one week followed by two-third partial hepatectomy. Liver regeneration rate, serum functional markers, alanine aminotransferase (ALT), asparate aminotransferase (AST) and bilirubin levels were determined 24 hours post-surgery. The result indicated that lisinopril administration increased liver regeneration rate and reduced ALT, AST and bilirubin levels of fibrotic rats following partial hepatectomy. Histopathological liver evaluation showed that hepatic cell plate width was decreased, sinusoids were widened, and fibrosis was reduced by lisinopril treatment in regenerating fibrotic livers. In conclusion ACE-Inhibitor, lisinopril affected the regeneration of fibrotic liver with improved functional capability after partial hepatectomy.
Partial Hepatectomy, Hepatic Fibrosis, Alanine Aminotransferase, Asparate Aminotransferase, Bilirubin
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