Mechanism of Action of Trigonella in Cancer Prevention
Cancer known as the most common cause of death worldwide. Synthetic medicines cause serious side effects and associated with drug resistance. Therefor utilization of natural compounds could be an alternative concept to prevent the development of tumors. Targeting the proliferation or inducing apoptosis is a major critical point in the cancer therapy. Medicinal plants have been related to fight many illnesses including cancer. They have acquired glory as inexpensive and inoffensive substitution as compared to the synthetic drugs. Consumption a diet rich in natural plant can supply an ambience of phytochemicals that possess health-prophylactic effects. Trigonella is one of the famous curative plants and used as hot drinks. It is used as anti-tumor agent in many researches. However, proliferation and the induction of apoptosis are regulated by several mechanisms. The current review will discuss the mechanism by which this herb gained its anti-tumor and immune-boosting activities.
Trigonella, Mechanism of Action, Cancer Prevention
[1]
Acharya SN, Thomas JE, Basu SK. (2008). Fenugreek (Trigonella foenum-graecum L.) an alternative crop for semiarid regions of North America. Crop Sci; 48:841-853.
[2]
Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan, ST, Sung B. (2008). Potential of spice derived phytochemicals for cancer prevention. Planta Med; 74:1560-1569.
[3]
Aggarwal BB, Shishodia S. (2006). Molecular target of dietary agents for prevention and therapy of cancer. Biochem Pharmacol; 71:1397-1421.
[4]
Ahmad N, Adhami VM, Afaq F, Feyes DK, Mukhtar H. (2001). Resveratrol causes waf-1/p21-mediated phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res; 7: 1466 -1473.
[5]
Al-Daghri NM, Alokail MS, Alkharfy KM, Mohammed AK, Abd-Alrahman SH, Yakout SM, Amer OE, Krishnaswamy S. (2012). Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells. BMC Complement Altern Med; 12:202.
[6]
Ali F, Khan R, Khan AQ, Lateef MA, Maqbool T, Sultana S. (2013). Assessment of Augmented Immune Surveillance and Tumor Cell Death by Cytoplasmic Stabilization of p53 as a Chemopreventive Strategy of 3 Promising Medicinal Herbs in Murine 2-Stage Skin Carcinogenesis. Integr Cancer Ther; 13(4):351-367
[7]
Alshatwi AA. (2010). Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res; 17: 167.
[8]
Alshatwi AA, Shafi G, Hasan TN, Syed NA, Khoja KK. (2013). Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pac J Cancer Prev; 14(10):5783-5788.
[9]
Amin A, Alkaabi A, Al-Falasi S, Daoud SA. (2005). Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer. Cell Biol Int; 29(8):687-694.
[10]
Bhatia K, Kaur M, Atif F, Ali M, Rehman H, Rahman S, Raisuddin S. (2006). Aqueous extract of Trigonella foenum-graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food Chem Toxicol.; 44(10):1744-1750.
[11]
Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S. (2003). Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol; 3(2):257-265.
[12]
Carmeliet P, Jain RK. (2000). Angiogenesis in cancer and other diseases. Nature; 407:249–257.
[13]
Chatterjee S, Goswami N, Bhatnagar P, Kumar M, Kumar A. (2013). Antimutagenic and chemopreventive potentialities of fenugreek (Trigonella foenum-graecum) seed extract. Oxid Antioxid Med Sci; 2(1):45-53
[14]
Chatterjee S, Kumar M, Kumar A. (2012). Chemomodulatory Effect of Trigonella foenum graecum (L.) Seed Extract on Two Stage Mouse Skin Carcinogenesis. Toxicol Int; 19(3):287-294.
[15]
Chen N, Debnath J. (2010). Autophagy and tumorigenesis. FEBS Lett; 584(7):1427-1435.
[16]
Chen PS, Shih YW, Huang HC, Cheng HW. (2011). Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. PLoS One; 6(5):e20164.
[17]
Chiang C-T, Way T-D, Tsai S-J, Lin J-K. (2007). Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett; 581: 5735–5742.
[18]
Chien CS, Shen KH, Huang JS, Ko SC, Shih YW. (2010). Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells. Mol Cell Biochem; 333: 169–180.
[19]
Choi KW, Park HJ, Jung DH, Kim TW, Park YM, Kim BO, Sohn EH, Moon EY, Um SH, Rhee DK, Pyo S. (2010). Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways. Vascul Pharmacol; 53:273-280
[20]
Corbiere C, Liagre B, Terro F, Beneytout JL. (2004). Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells. Cell Res; 14: 188–196.
[21]
Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, kundu SC, Mandal M. (2012). Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PLoS One; 7(10):e46641.
[22]
Devasena T, Menon VP. (2002). Enhancement of circulatory antioxidants by fenugreek during 1,2-dimethylhydrazine-induced rat colon carcinogenesis. J Biochem Mol Biol Biophys; 6(4):289-292.
[23]
Devasena T, Menon VP. (2003). Fenugreek affects the activity of beta-glucuronidase and mucinase in the colon. Phytother Res; 17(9):1088-1091.
[24]
Devasena T, Menon VP. (2007). Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis. Ital J Biochem; 56(1):28-34.
[25]
Earnshaw WC, Martins LM, Kaufmann SH. (1999). Mammalian caspases Structure, activation, substrates, and functions during apoptosis. Ann Rev Biochem; 68: 383-424.
[26]
Fleiss P. (1988). Herbal remedies for the breastfeeding mother. Mothering Summer: 68-71.
[27]
Greenwald P, Kelloff G, Burch-Whitman C. (1995). Chemoprevention. CA Cancer J. Clin. 45:31-49.
[28]
Hibasami H, Moteki H, Ishikawa K, Katsuzaki H, Imai K, Yoshioka K, Ishii Y, Komiya T. (2003). Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III. Int J Mol Med; 11(1):23-36.
[29]
Jagadeesan J, Nandakumar N, Rengarajan T, Balasubramanian MP. (2012). Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J Environ Pathol Toxicol Oncol; 31(2):121-129.
[30]
Kaviarasan S, Vijayalakshmi K, Anuradha CV. (2004). Polyphenol-rich extract of fenugreek seeds protect erythrocytes from oxidative damage. Plant Food Hum Nutr; 59(4): 143-147.
[31]
Kawabata T, Cui MY, Hasegawa T, Takano F, Ohta T. (2011). Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds. Planta Med; 77(7):705-710.
[32]
Klionsky DJ, Emr SD. (2000). Autophagy as a regulated pathway of cellular degradation. Science; 290(5497):1717-1721.
[33]
Leung AY, Foster S. (1996). Encyclopaedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed, John Wiley & Sons, New York, NY, USA.
[34]
Levine B, Kroemer G. (2008). Autophagy in the pathogenesis of disease. Cell; 132(1):27-42.
[35]
Lewiecki EM. (2009). Phytoestrogens and their role in the management of postmenopausal osteoporosis. South Med J; 102: 111-122.
[36]
Malik F, Kumar A, Bhushan S, Khan S, Bhatia A, Suri KA, Qazi GN, Singh J. (2007). Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound with aferin A with concomitant protection by N-acetylcysteine. Apoptosis; 12(11): 2115-2133.
[37]
Manivannan J, Arunagiri P, Sivasubramanian J, Balamurugan E. (2013). Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular alterations in chronic renal failure rats. Int J Nutr Pharmacol Neurol Dis; 3(3):289-293
[38]
Muraki E, Hayashi Y, Chiba H, Tsunoda N, Kasono K. (2011). Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats. Lipids Health Dis; 10:240.
[39]
Neelakantan N, Narayanan M, de Souza RJ, van Dam RM. (2014). Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J; 13:7
[40]
Oliveria SA, Christos PJ, Berwick M. (1997). The role of epidemiology in cancer prevention. Proc Soc Exp Biol Med; 216:142-150.
[41]
Petropoulos GA. (2002). Fenugreek: The genus Trigonella. Taylor and Francis, London, UK.
[42]
Pommier Y, Sordet O, Antony S, Haywrd RL, Kohn KW. (2004). Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene; 23: 2934-2949.
[43]
Prabhakar PK, Doble M. (2011). Mechanism of action of natural products used in the treatment of diabetes mellitus. Chin J Integr Med; 17(8):563-574.
[44]
Raju J, Patlolla JM, Swamy MV, Rao CV. (2004). Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev; 13(8):1392-1398.
[45]
Riedl SJ, Shi Y. (2004). Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol; 5: 897-907.
[46]
Samuels Y, Ericson K. (2006). Oncogenic PI3K and its role in cancer. Curr Opin Oncol;18:77–82.
[47]
Sebastian KS, Thampan RV. (2007). Differential effects of soybean and fenugreek extracts on the growth of MCF-7 cells. Chem Biol Interact; 170(2):135-143.
[48]
Seo KW, Kim GJ, Park M, Kim TW, Kim HJ. (2000). Effects of phenethylisothiocyanate on the expression of glutathione S transferase and hepatotoxicity induced by acetaminophen. Xenobiotica; 30:535-543.
[49]
Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, Lei DK. (2009). Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa. Cancer Cell Int; 27: 9-29.
[50]
Shabbeer S, Sobolewski M, Anchoori RK, Kachhap S, Hidalgo M, Jimeno A, Davidson N, Carducci MA, Khan SR. (2009). Fenugreek: a naturally occurring edible spice as an anticancer agent. Cancer Biol Ther; 8(3):272-278.
[51]
Shishodia S, Aggarwal BB. (2006). Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene; 25(10):1463-1473.
[52]
Silambarasan T, Raja B. (2012). Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. Eur J Pharmacol; 679:81-89
[53]
Sirtori CR, Galli C, Anderson JW, Sirtori E, Arnoldi A. (2009). Functional foods for dyslipidaemia and cardiovascular risk prevention. Nutr Res Rev; 22(2):244-261.
[54]
Sreeja S, Thampan RV. (2004). Proteins which mediate the nuclear entry of goat uterine non activated estrogen receptor (naER) following naER internalization from the plasma membrane. Mol Cell Biochem; 259: 141-148.
[55]
Sreeja S, Anju VS, Sreeja S. (2010). In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds. Ind J Med Res;131:814-819.
[56]
Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C. (2009). Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int J Cancer; 125(4):961-967.
[57]
Sur P, Das M, Gomes A, Vedasiromoni JR, Sahu NP, Banerjee S, Sharma RM, Ganguly DK. (2001). Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent. Phytother Res; 15(3):257-259.
[58]
Tiran D. (2003). The use of fenugreek for breast feeding women. Complem Therap Nursing Midwifery; 9: 155-156.
[59]
Ulbricht C, Basch E, Burke D, Cheung L, Ernst E, Giese N, Foppa I, Hammerness P, Hashmi S, Kuo G, Miranda M, Mukherjee S, Smith M, Sollars D, Tanguay-Colucci S, Vijayan N, Weissner W. (2007). Fenugreek (Trigonella foenum-graecum L. Leguminosae): an evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother; 7(3-4):143-177.
[60]
Varjas T, Nowrasteh G, Budan F, Horvath G, Cseh J, Gyongyi Z, Makai S, Ember I. (2011). The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes. Phytother Res; 25(2):221-227.
[61]
Wattenberg LW. (1996). Chemoprevention of cancer. Prev Med; 25:44-55.
[62]
Yang SX, Steinberg SM, Nguyen D, Wu TD, Modrusan Z, Swain SM. (2008). Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer. Clin Cancer Res; 14: 5893–5899.
[63]
Zargar S. (2014). Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi J Biol Sci; 21 (2):139–145.
